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CN

CN
Biomarker

Overview

 

  • Immune profiling/biomarker platforms to support pre-clinical research

    • Flow Cytometry：>20 channel flow cytometry analysis, cover >60 cell marker/biomarker, baseline TIL (tumor-infiltrating leukocytes) data from >30 models, service covered TIL analysis, checkpoint/co-stimulatory marker analysis, in vitro/in vivo phospho-flow, function analysis of immune cells, high dimensional data mining

    • Pathology/multiplex IF：FFPE preparation/IHC/IF to support pre-clinical pathology diagnosis for drug safety evaluation, efficacy evaluation, etc. Multiplex IF focusing on immune microenvironment analysis, including immune cell infiltration analysis, spatial-proximity analysis, secretory protein source determination, complex tissue structure determination, evaluation of gene expression regulation

    • NanoString-based gene expression profiling：Gene expression profiling with up to 800 genes in one panel, enabling GEP in difficult samples like FFPE, panel covering hot genes/pathways/function in immunology/oncology.

    • Single-cell RNA sequencing platform and bioinformatics services: One-stop service covering sample processing, library preparation, sequencing and bioinformatics analysis. Enabling cell type identification and phenotyping, differential gene expression analysis, functional enrichment and cell-cell interaction.

    • Molecular platform: qPCR to support efficacy and safety evaluation (e.g. target gene copy number variation in CAR-T cells, and replication competent lentivirus (RCL) level in CAR-T cell).

 

  • Clinical biomarker platform

    • CAP-certified pathology, flow cytometry and molecular biology lab, GCP compliance, strong team composed of well-trained immunologists, board-certified pathologists, biomarker experts and qualified technicians

    • Pathology lab: Provide biomarker testing in clinical studies, including H&E and histology analysis, FFPE sample process and slide cutting, IHC/ICC,IF, EHC, TCT, FISH, DISH, RNAscope, multiplex-IF, etc.

    • Flow cytometry lab: >40 biomarker/cell markers, services covering immune-phenotyping, biomarker analysis, PD/PK for cell therapy, biomarker analysis, receptor occupancy, phospho-biomarker analysis and tumor microenvironment analysis

    • NanoString-based gene expression profiling：Gene expression profiling with up to 800 genes in one panel, enabling GEP in difficult samples like FFPE, panel covering hot genes/pathways/function in immunology/oncology.

    • Molecular Lab: qPCR, cMET exon14 skipping and EGFR mutation testing.