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Metabolic Diseases

NASH and NAFLD

 

WuXi AppTec has developed and validated animal models of NASH that captures key features seen in man. Mice are first fed with high-fat diet (HFD) to induced obesity. Carbon tetrachloride is then used to induce liver damages, leading to inflammation, cell death and fibrosis.

 

 

WuXi AppTec’s HFD-CCL4 NASH Model

 

  • Fibrosis validation
  • Histopathology validation
  • Biomarkers validation
  • In vivo efficacy test for NASH and related animals models
  • Animal study design

 

 

Diabetes; Obesity, Dyslipidemia

 

 

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