Deuteration Chemistry

We offer custom-tailored monomers and screening compounds containing deuterium atoms

Roles of Deuterium-labelled Compounds

• Study of reaction mechanisms and kinetics

• Analysis of drug metabolism

• Structural elucidation of biological macromolecules

• Quantitative analysis of environmental pollutants and residual pesticides

• Used as functional materials and as internal standards in analytical methods

• Significantly improve the pharmacokinetic properties (ADMET)

The first deuterium drug AUSTEDO/SD-809 (Auspex/Teva) was approved by FDA in April 2017.

Our Capabilities:

Synthesis of diverse deuterated monomers and final targets

• Excellent skill of synthetic route design

• Experienced in deuteration at various sites of molecules

• Capable of achieving high ratio of deuterium incorporation

• Conducted many challenged deuteration rxns

• Reaction scale: milligram to gram

• Maximally 16 deuteriums were incorporated to a single molecule

• Put together all kinds of deuteration reagents (LiAlD₄, D₂, D₂O, DCl, TFA-D…)

Reaction Types:

• Reduction of Carbonyl, Imine, Alkene or Alkyne, CN and NO₂

• Metal/D, X/D Exchange

• D/H exchange occurs at Aromatic, Allylic or Carbonyl α position

• α-Deuteration of Amines and Alcohols

Others…

Business Contact： 

• North America: Declan Ryan,  declan.ryan@wuxiapptec.com
• Europe and Israel: Dave Madge,  dave_madge@wuxiapptec.com
• China: Marcher Xu,  xu_longji@wuxiapptec.com
• Japan: Yan Zhu,  yan_zhu@wuxiapptec.com
• Korea: Suk Young Cho,  sycho@wuxiapptec.com
• Customer Service: IDSU_CS@wuxiapptec.com